(19)

(11)

EP 0 770 131 A1

(12)

(43) Date of publication: 02.05.1997 Bulletin 1997/18 (21) Application number: 95923485.0 (22) Date of filing: 03.07.1995

(51) International Patent Classification (IPC):  C07K 14/ 04( . ) A61K 39/ 00( . ) C12N 15/ 38( . ) (86) International application number: PCT/GB1995/001566 (87) International publication number: WO 1996/001900 (25.01.1996 Gazette 1996/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.07.1994 GB 19940013751 (71) Applicant: BRITISH BIOTECH PHARMACEUTICALS LIMITED Cowley Oxford, OX4 5LY (GB)	(72) Inventors: LAYTON, Guy Timothy British Biotech Cowley Oxford OX4 5LY (GB) GARCIA-VALCARCEL MUNOZ-REPISO, Mercedes British Cowley Oxford OX4 5LY (GB) FOWLER, Wendy Jane Sandford on Thames, Oxford (GB) HARPER, David Richard The Medical College London EC1A 7BE (GB) (74) Representative: Walls, Alan James  British Biotech Pharmaceuticals Ltd., Watlington Road Oxford OX4 5LY Oxford OX4 5LY (GB)