(19)

(11)

EP 0 771 207 A1

(12)

(43) Date of publication: 07.05.1997 Bulletin 1997/19 (21) Application number: 95927310.0 (22) Date of filing: 19.07.1995

(51) International Patent Classification (IPC):  A61K 9/ 20( . ) A61K 33/ 08( . ) A61P 1/ 10( . ) A61K 9/ 48( . ) A61K 45/ 00( . ) (86) International application number: PCT/US1995/009166 (87) International publication number: WO 1996/002261 (01.02.1996 Gazette 1996/06)

(84) Designated Contracting States: AT BE CH DE DK FR GB IT LI NL SE (30) Priority: 19.07.1994 US 19940277542 (71) Applicant: STERLING WINTHROP INC. Pittsburgh PA 15219-2507 (US)	(72) Inventors: O'KEEFFE, Kenneth J. Seaford, NY 11783 (US) VANDENBROUCKE, Pol Upper Montclair, NJ 07043 (US) (74) Representative: White, Susan Mary, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)