(19)

(11)

EP 0 771 351 A1

(12)

(43) Date of publication: 07.05.1997 Bulletin 1997/19 (21) Application number: 95922211.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 16/ 12( . ) C12N 15/ 31( . ) A61K 39/ 00( . ) C07K 14/ 31( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 445( . ) (86) International application number: PCT/US1995/007100 (87) International publication number: WO 1995/034655 (21.12.1995 Gazette 1996/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1994 US 19940254968 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventors: CHEUNG, Ambrose New York, NY 10021 (US) FISCHETTI, Vincent, A. West Hempstead, NY 11552 (US) (74) Representative: Jones, Helen Marjorie Meredith  Gill Jennings & Every, Broadgate House, 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)