ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF - Patent 0772585

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EP 0 772 585 A1

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(43)	Date of publication:
	14.05.1997 Bulletin 1997/20

(21)	Application number: 95929029.0

(22)	Date of filing: 27.07.1995

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International Patent Classification (IPC):

C07D 317/ 58^{( . )}
A61K 31/ 215^{( . )}
A61K 31/ 36^{( . )}
A61P 1/ 00^{( . )}
A61P 3/ 00^{( . )}
A61P 9/ 10^{( . )}
A61P 25/ 26^{( . )}
A61P 43/ 00^{( . )}
C07C 217/ 34^{( . )}
C07C 311/ 21^{( . )}
C07D 317/ 46^{( . )}
C07F 9/ 32^{( . )}

A61K 31/ 195^{( . )}
A61K 31/ 357^{( . )}
A61K 31/ 66^{( . )}
A61P 1/ 04^{( . )}
A61P 3/ 08^{( . )}
A61P 25/ 24^{( . )}
A61P 29/ 00^{( . )}
C07C 217/ 30^{( . )}
C07C 311/ 08^{( . )}
C07C 323/ 25^{( . )}
C07F 9/ 30^{( . )}
C07F 9/ 40^{( . )}

(86)	International application number:
	PCT/EP1995/003037

(87)	International publication number:
	WO 1996/004233 (15.02.1996 Gazette 1996/08)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	SI

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Priority:

29.07.1994 GB 19940015304
17.11.1994 GB 19940023179
24.05.1995 GB 19950010485

(71)	Applicant: SMITHKLINE BEECHAM PLC
	Brentford, Middlesex TW8 9EP (GB)

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Inventors:

BEELEY, Lee J., SmithKline Beecham Pharmaceuticals
Epsom, Surrey KT18 5XQ (GB)
THOMPSON, Mervyn, SmithKline Beecham Pharmaceut.
Harlow, Essex CM199 5AD (GB)
DEAN, David K., SmithKline Beecham Pharmaceuticals
Epsom, Surrey KT18 5XQ (GB)
KOTECHA, Nikesh R., SmithKline Beecham Pharmaceut.
Harlow, Essex CM19 5AD (GB)
BERGE, John M., SmithKline Beecham Pharmaceuticals
Epsom, Surrey KT18 5XQ (GB)
WARD, Robert W., SmithKline Beecham Pharmaceut.
Harlow, EssexCM19 5xAD (GB)

(74)	Representative: Rutter, Keith, Dr.
	SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)

(54)	ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF