(19)

(11)

EP 0 772 679 A1

(12)

(43) Date of publication: 14.05.1997 Bulletin 1997/20 (21) Application number: 95922628.0 (22) Date of filing: 21.06.1995

(51) International Patent Classification (IPC):  C07K 14/ 435( . ) A61K 38/ 00( . ) C12N 15/ 12( . ) A61K 39/ 00( . ) (86) International application number: PCT/GB1995/001454 (87) International publication number: WO 1995/035370 (28.12.1995 Gazette 1996/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 22.06.1994 GB 19940012467 22.06.1994 GB 19940012470 (71) Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE London SW7 2BB (GB)	(72) Inventors: AGNEW, A., Imperial College of Sci. Tech. & Medic. London SW7 2BBondon SW7 2BB (GB) GUTSMANN, Volker London NW3 1AD (GB) (74) Representative: Maschio, Antonio  D Young & Co, 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)