(19)
(11) EP 0 773 933 A1

(12)

(43) Date of publication:
21.05.1997 Bulletin 1997/21

(21) Application number: 95925584.0

(22) Date of filing: 10.07.1995
(51) International Patent Classification (IPC): 
A61K 31/ 47( . )
A61P 25/ 00( . )
A61K 31/ 473( . )
C07D 221/ 18( . )
(86) International application number:
PCT/US1995/008598
(87) International publication number:
WO 1996/002513 (01.02.1996 Gazette 1996/06)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
LT LV SI

(30) Priority: 15.07.1994 US 19940275342

(71) Applicants:
  • PURDUE RESEARCH FOUNDATION
    West Lafayette, IN 47907-1021 (US)
  • THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Chapel Hill, North Carolina 27599-4100 (US)

(72) Inventors:
  • NICHOLS, David, E.
    West LaFayette, IN 47907 (US)
  • MAILMAN, Richard, B.
    Chapel Hill, NC 27514 (US)

(74) Representative: Schwarzensteiner, Marie-Luise 
Lewald - Grape - Schwarzensteiner Rindermarkt 6
80331 München
80331 München (DE)

   


(54) OPTICALLY ACTIVE ISOMERS OF DIHYDREXIDINE AND ITS SUBSTITUTED ANALOGS