(19)

(11)

EP 0 773 989 A1

(12)

(43) Date of publication: 21.05.1997 Bulletin 1997/21 (21) Application number: 96903342.0 (22) Date of filing: 11.01.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1996/000074 (87) International publication number: WO 1996/034091 (31.10.1996 Gazette 1996/48)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.04.1995 US 19950430913 (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, WI 53707-7365 (US)	(72) Inventors: DeLUCA, Hector F. Deerfield, WI 53531 (US) ARBOUR, Nancy C. Muscatine, IA 52761 (US) PRAHL, Jean M. Madison, WI 53719 (US) ROSS, Troy K. Muscatine, IA 52761 (US) ZIEROLD, Claudia Madison, WI 53715 (US) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)