(19)

(11)

EP 0 773 993 A1

(12)

(43) Date of publication: 21.05.1997 Bulletin 1997/21 (21) Application number: 95928825.0 (22) Date of filing: 10.08.1995

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 14/ 705( . ) C12N 5/ 00( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 35/ 12( . ) C07K 14/ 71( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1995/010250 (87) International publication number: WO 1996/006165 (29.02.1996 Gazette 1996/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.08.1994 US 19940292565 (71) Applicants: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US) BIOTRANSPLANT, INC Charlestown, MA 02129 (US)	(72) Inventors: SACHS, David H. Newton, MA 02166 (US) SYKES, Megan Boston, MA 02129-4230 (US) BAETSCHER, Manfred Winchester, MA 01890 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)