ANTIBODIES THAT BIND A CONFORMATIONALLY ALTERED CD4 MOLECULE INDUCED UPON HUMAN IMMUNODEFFICIENCY VIRUS BINDING - Patent 0774000

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EP 0 774 000 A1

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(43)	Date of publication:
	21.05.1997 Bulletin 1997/21

(21)	Application number: 95928088.0

(22)	Date of filing: 19.07.1995

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 39/ 395^{( . )}
C07K 16/ 28^{( . )}
C12N 15/ 02^{( . )}
C12P 21/ 08^{( . )}
C12R 1/ 19^{( . )}

A61K 38/ 00^{( . )}
C07K 14/ 73^{( . )}
C12N 1/ 21^{( . )}
C12N 15/ 13^{( . )}
A61K 39/ 00^{( . )}

(86)	International application number:
	PCT/US1995/009114

(87)	International publication number:
	WO 1996/002647 (01.02.1996 Gazette 1996/06)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

19.07.1994 US 19940277080
13.09.1994 US 19940305903

(71)	Applicant: BETH ISRAEL HOSPITAL
	Boston Massachusetts 02215 (US)

(72)	Inventors:
	BACHELDER, Robin Newton, MA 02167 (US) LETVIN, Norman Newton, MA 02158 (US)

(74)	Representative: Holdcroft, James Gerald, Dr., et al
	Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)

(54)	ANTIBODIES THAT BIND A CONFORMATIONALLY ALTERED CD4 MOLECULE INDUCED UPON HUMAN IMMUNODEFFICIENCY VIRUS BINDING