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EP 0 774 965 A1

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(43) Date of publication: 28.05.1997 Bulletin 1997/22 (21) Application number: 95929396.0 (22) Date of filing: 07.08.1995

(51) International Patent Classification (IPC):  A61K 31/ 357( . ) A61P 9/ 00( . ) A61P 9/ 10( . ) A61P 11/ 00( . ) A61P 15/ 00( . ) C07D 317/ 60( . ) C07D 409/ 12( . ) A61K 31/ 36( . ) A61P 9/ 08( . ) A61P 9/ 12( . ) A61P 13/ 02( . ) C07C 65/ 24( . ) C07D 405/ 12( . ) (86) International application number: PCT/US1995/009967 (87) International publication number: WO 1996/004905 (22.02.1996 Gazette 1996/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.08.1994 US 19940287374 22.08.1994 US 19940294232 07.06.1995 US 19950473172 (71) Applicant: Merck & Co., Inc. Rahway New Jersey 07065-0900 (US)

(72) Inventors: BAGLEY, Scott W. Rahway, NJ 07065 (US) BROTEN, Theodore P. Rahway, NJ 07065 (US) CHAKRAVARTY, Prasun K. Rahway, NJ 07065 (US) DHANOA, Daljit S. Rahway, NJ 07065 (US) FITCH, Kenneth J. Rahway, NJ 07065 (US) GREENLEE, William J. Rahway, NJ 07065 (US) KEVIN, Nancy Jo Rahway, NJ 07065 (US) KIECZYKOWSKI, Gerard R. Rahway, NJ 07065 (US) MATTHEWS, Jay M. Rahway, NJ 07065 (US) PETTIBONE, Douglas J. Rahway, NJ 07065 (US) RIVERO, Ralph A. Rahway, NJ 07065 (US) TATA, JAMES R. Rahway, NJ 07065 (US) WALSH, Thomas F. Rahway, NJ 07065 (US) WILLAMS, David L., Jr. Rahway, NJ 07065 (US) TOUPENCE, Richard B. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James, et al  European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)