(19)

(11)

EP 0 775 122 A1

(12)

(43) Date of publication: 28.05.1997 Bulletin 1997/22 (21) Application number: 95927813.0 (22) Date of filing: 01.08.1995

(51) International Patent Classification (IPC):  A61K 31/ 41( . ) A61P 31/ 10( . ) C07D 521/ 00( . ) A61P 31/ 04( . ) C07D 249/ 08( . ) (86) International application number: PCT/GB1995/001816 (87) International publication number: WO 1996/004257 (15.02.1996 Gazette 1996/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 02.08.1994 GB 19940015617 (71) Applicant: ZENECA LIMITED London W1Y 6LN (GB)	(72) Inventors: LADD, Richard, Maurice Cheshire SK12 1NU (GB) CHEETHAM, Francis, David Stockport Cheshire SK7 6BW (GB) MOBBS, Bryan, Edward Cheshire SK11 8NZ (GB) (74) Representative: Denerley, Paul Millington, et al  Intellectual Property Department ZENECA Pharmaceuticals Mereside Alderley Park Macclesfield, Chesire SK10 4TG Macclesfield, Chesire SK10 4TG (GB)