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(11)

EP 0 776 359 A1

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(43) Date of publication: 04.06.1997 Bulletin 1997/23 (21) Application number: 94923515.0 (22) Date of filing: 18.07.1994

(51) International Patent Classification (IPC):  A01H 5/ 00( . ) C07H 21/ 04( . ) C07K 14/ 725( . ) C12N 5/ 10( . ) C12N 15/ 62( . ) A01K 67/ 027( . ) C07K 14/ 705( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1994/008008 (87) International publication number: WO 1995/002684 (26.01.1995 Gazette 1995/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.07.1993 US 19930093499 07.01.1994 US 19940179143 (71) Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Stanford California 94305 (US) THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02114 (US)

(72) Inventors: CRABTREE, Gerald R. Woodside, CA 94062 (US) SCHREIBER, Stuart L. Harvard University Cambridge, MA 02138 (US) SPENCER, David M. Los Altos, CA 94022 (US) WANDLESS, Thomas J. Harvard University Cambridge, MA 02138 (US) BELSHAW, Peter Harvard University Cambridge, MA 02138 (US) (74) Representative: Marchant, James Ian, et al  Elkington and Fife, Prospect House, 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)