(19)

(11)

EP 0 776 364 A1

(12)

(43) Date of publication: 04.06.1997 Bulletin 1997/23 (21) Application number: 95926863.0 (22) Date of filing: 12.07.1995

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 16/ 28( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 02( . ) C12R 1/ 91( . ) C07K 14/ 705( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) C12Q 1/ 68( . ) (86) International application number: PCT/EP1995/002728 (87) International publication number: WO 1996/006167 (29.02.1996 Gazette 1996/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.08.1994 GB 19940016554 (71) Applicant: CIBA-GEIGY AG 4002 Basel (CH)	(72) Inventors: FLOR, Peter Josef D-79089 Freiburg (DE) KUHN, Rainer D-79540 Lörrach (DE) LINDAUER, Kristin CH-4056 Basel (DE) PÜTTNER, Irene CH-4053 Basle (CH) KNÖPFEL, Thomas CH-4310 Rheinfelden (CH)