(19)

(11)

EP 0 777 688 A1

(12)

(43) Date of publication: 11.06.1997 Bulletin 1997/24 (21) Application number: 95931169.0 (22) Date of filing: 18.08.1995

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 38/ 04( . ) A61K 38/ 16( . ) A61K 39/ 395( . ) C07K 14/ 705( . ) C12N 5/ 00( . ) C12N 5/ 12( . ) G01N 33/ 577( . ) A61K 38/ 00( . ) A61K 38/ 08( . ) A61K 39/ 00( . ) C07K 14/ 47( . ) C07K 16/ 28( . ) C12N 5/ 06( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) (86) International application number: PCT/EP1995/003311 (87) International publication number: WO 1996/006113 (29.02.1996 Gazette 1996/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.08.1994 EP 19940202392 (71) Applicant: Akzo Nobel N.V. 6824 BM Arnhem (NL)	(72) Inventors: VAN DUIN, Marcel NL-5237 HB 's-Hertogenbosch (NL) GROOTENHUIS, Arij, Jan NL-5032 BH Tilburg (NL) BUNSCHOTEN, Evert, Johannes NL-5384 HD Heesch (NL) (74) Representative: Ogilvie-Emanuelson, Claudia Maria, et al  Patent Department Pharma N.V. Organon P.O. Box 20 5340 BH Oss 5340 BH Oss (NL)