(19)

(11)

EP 0 781 336 A1

(12)

(43) Date of publication: 02.07.1997 Bulletin 1997/27 (21) Application number: 96923586.0 (22) Date of filing: 28.06.1996

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) A61K 38/ 55( . ) A61K 48/ 00( . ) C07K 14/ 47( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) G01N 33/ 573( . ) A61K 31/ 70( . ) A61K 39/ 395( . ) A61P 29/ 00( . ) C07K 16/ 18( . ) C12N 9/ 12( . ) C12N 15/ 12( . ) G01N 33/ 566( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/011170 (87) International publication number: WO 1997/002347 (23.01.1997 Gazette 1997/05)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 28.06.1995 US 19950000722 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto , CA 94304 (US)	(72) Inventors: HAWKINS, Phillip, R. Mountain View, CA 94034 (US) AU-YOUNG, Janice Berkeley, CA 94702 (US) GUEGLER, Karl, J. Menlo Park, CA 94025 (US) WILDE, Craig, G. Sunnyvale, CA 94087 (US) (74) Representative: Wright, Simon Mark, et al  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)