(19)

(11)

EP 0 783 489 A1

(12)

(43) Date of publication: 16.07.1997 Bulletin 1997/29 (21) Application number: 95932228.0 (22) Date of filing: 25.09.1995

(51) International Patent Classification (IPC):  C07C 311/ 19( . ) C07D 401/ 12( . ) A61K 38/ 00( . ) C07D 209/ 16( . ) C07K 5/ 06( . ) (86) International application number: PCT/JP1995/001933 (87) International publication number: WO 1996/010014 (04.04.1996 Gazette 1996/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 27.09.1994 JP 19940231839 (71) Applicant: Takeda Chemical Industries, Ltd. Osaka-shi, Osaka 541 (JP)	(72) Inventors: SOHDA, Takashi Takatsuki-shi Osaka 569 (JP) FUJISAWA, Yukio Kobe-shi Hyogo 658 (JP) YASUMA, Tsuneo Ibaraki-shi Osaka 567 (JP) MIZOGUCHI, Junji Suita-shi Osaka 565 (JP) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) 50667 Köln 50667 Köln (DE)