(19)

(11)

EP 0 783 509 A1

(12)

(43) Date of publication: 16.07.1997 Bulletin 1997/29 (21) Application number: 94931757.0 (22) Date of filing: 20.09.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 35/ 76( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 14/ 47( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 31/ 70( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C07K 16/ 18( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1994/010644 (87) International publication number: WO 1996/009311 (28.03.1996 Gazette 1996/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: MOORE, Paul, A. MCLEAN, VIRGINIA 22102 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)