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(11)

EP 0 783 517 A2

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(43) Date of publication: 16.07.1997 Bulletin 1997/29 (21) Application number: 95935104.0 (22) Date of filing: 26.09.1995

(51) International Patent Classification (IPC):  C07D 233/ 64( . ) A61K 38/ 55( . ) A61P 43/ 00( . ) C07K 5/ 02( . ) C07K 5/ 06( . ) C07K 5/ 08( . ) A61K 38/ 00( . ) A61K 31/ 415( . ) A61P 35/ 00( . ) C07D 233/ 54( . ) C07K 5/ 03( . ) C07K 5/ 062( . ) C07K 5/ 10( . ) (86) International application number: PCT/US1995/012224 (87) International publication number: WO 1996/010034 (04.04.1996 Gazette 1996/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.09.1994 US 19940314974 21.09.1995 US 19950526244 (71) Applicant: Merck & Co., Inc. Rahway New Jersey 07065-0900 (US)

(72) Inventors: ANTHONY, Neville, J. Rahway, NJ 07065 (US) DESOLMS, S., Jane Rahway, NJ 07065 (US) GOMEZ, Robert, P. Rahway, NJ 07065 (US) GRAHAM, Samuel, L. Rahway, NJ 07065 (US) HUTCHINSON, John, H. Rahway, NJ 07065 (US) STOKKER, Gerald, E. Rahway, NJ 07065 (US) (74) Representative: Thompson, John Dr., et al  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)