(19)

(11)

EP 0 783 568 A1

(12)

(43) Date of publication: 16.07.1997 Bulletin 1997/29 (21) Application number: 95931336.0 (22) Date of filing: 15.09.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 43/ 00( . ) C12N 5/ 10( . ) A61K 48/ 00( . ) A61K 35/ 36( . ) C12N 5/ 077( . ) A61K 35/ 12( . ) (86) International application number: PCT/GB1995/002187 (87) International publication number: WO 1996/009373 (28.03.1996 Gazette 1996/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.09.1994 GB 19940019048 (71) Applicant: BRITISH TECHNOLOGY GROUP LIMITED London SE1 6BU (GB)	(72) Inventors: WATT, Diana, Joan Mannings Heath West Sussex RH13 6HZ (GB) BETTENCOURT DE MEDEIROS RELVAS, Joao, Carlos P-3000 Coimbra (PT) (74) Representative: Percy, Richard Keith  Patents Department British Technology Group Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)