INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES - Patent 0784478

(19)

(11)

EP 0 784 478 A1

(12)

(43)	Date of publication:
	23.07.1997 Bulletin 1997/30

(21)	Application number: 95933865.0

(22)	Date of filing: 12.09.1995

(51)

International Patent Classification (IPC):

G01N 33/ 50^{( . )}
A61K 38/ 22^{( . )}
A61K 45/ 00^{( . )}
A61K 49/ 00^{( . )}
A61P 43/ 00^{( . )}
C07K 14/ 72^{( . )}
C12N 15/ 12^{( . )}
G01N 33/ 53^{( . )}

A61K 38/ 00^{( . )}
A61K 39/ 395^{( . )}
A61K 48/ 00^{( . )}
A61P 37/ 06^{( . )}
C07K 14/ 575^{( . )}
C07K 16/ 28^{( . )}
G01N 33/ 15^{( . )}

(86)	International application number:
	PCT/US1995/011937

(87)	International publication number:
	WO 1996/008268 (21.03.1996 Gazette 1996/13)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30)

Priority:

14.09.1994 US 19940307354

(71)	Applicants:
	PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02139 (US) BRIGHAM & WOMEN'S HOSPITAL Boston, MA 02115 (US)

(72)	Inventors:
	RUSSELL, Mary, E. Carlisle, MA 01742 (US) SAYEGH, Mohamed West Roxbury, MA 02132 (US) WATSCHINGER, Bruno A-1080 Vienna (AT)

(74)	Representative: Dzieglewska, Hanna Eva
	Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)

(54)	INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES