(19)

(11)

EP 0 785 767 A1

(12)

(43) Date of publication: 30.07.1997 Bulletin 1997/31 (21) Application number: 94925273.0 (22) Date of filing: 12.08.1994

(51) International Patent Classification (IPC):  A61K 8/ 00( . ) A61K 8/ 24( . ) A61Q 11/ 00( . ) A61K 8/ 18( . ) A61K 8/ 67( . ) (86) International application number: PCT/US1994/009185 (87) International publication number: WO 1995/005148 (23.02.1995 Gazette 1995/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 13.08.1993 US 19930107477 13.10.1993 US 19930135874 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: GALLOPO, Andrew, Robert Garfield, NJ 07026 (US) MAZZANOBILE, Salvatore Haworth, NJ 07641 (US) (74) Representative: Reeves, Julie Frances  SmithKline Beecham plc, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)