(19)

(11)

EP 0 785 777 A1

(12)

(43) Date of publication: 30.07.1997 Bulletin 1997/31 (21) Application number: 94922131.0 (22) Date of filing: 12.07.1994

(51) International Patent Classification (IPC):  A61K 9/ 16( . ) A61K 9/ 20( . ) A61K 9/ 00( . ) A61K 9/ 26( . ) (86) International application number: PCT/US1994/007817 (87) International publication number: WO 1995/002396 (26.01.1995 Gazette 1995/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 12.07.1993 US 19930090387 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: ADUSUMILLI, Prasad, S. Edison, NJ 08820 (US) (74) Representative: Reeves, Julie Frances  SmithKline Beecham plc, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)