(19)

(11)

EP 0 785 992 A1

(12)

(43) Date of publication: 30.07.1997 Bulletin 1997/31 (21) Application number: 95937629.0 (22) Date of filing: 25.10.1995

(51) International Patent Classification (IPC):  C12N 15/ 00( . ) C07K 14/ 705( . ) C07K 19/ 00( . ) C12N 15/ 62( . ) C07K 14/ 47( . ) C07K 14/ 715( . ) C12N 5/ 10( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1995/013776 (87) International publication number: WO 1996/012796 (02.05.1996 Gazette 1996/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE (30) Priority: 25.10.1994 US 19940328931 (71) Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Stanford California 94305 (US) THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02114 (US)	(72) Inventors: CRABTREE, Gerald R. Woodside, CA 94062 (US) SPENCER, David Los Altos, CA 94024 (US) HOLSINGER, Leslie Stanford, CA 94305 (US) GRAEF, Isabella Stanford, CA 94305 (US) SCHREIBER, Stuart Boston, MA 02115 (US) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)