(19)

(11)

EP 0 785 997 A2

(12)

(43) Date of publication: 30.07.1997 Bulletin 1997/31 (21) Application number: 95936657.0 (22) Date of filing: 10.11.1995

(51) International Patent Classification (IPC):  C07K 14/ 445( . ) A61K 39/ 00( . ) C12N 15/ 85( . ) (86) International application number: PCT/GB1995/002639 (87) International publication number: WO 1996/015237 (23.05.1996 Gazette 1996/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 11.11.1994 GB 19940022827 (71) Applicants: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE London SW7 2AZ (GB) UNIVERSITY OF LIVERPOOL Liverpool L69 3BX (GB)	(72) Inventors: SINDEN, Robert Edward Imperial College Prince Consort Road London SW7 2BB (GB) CRAMPTON, Julian Moray Liverpool School, Tropical Pembroke Place Liverpool L3 5QA (GB) (74) Representative: Harding, Charles Thomas, et al  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)