(19)

(11)

EP 0 788 540 A1

(12)

(43) Date of publication: 13.08.1997 Bulletin 1997/33 (21) Application number: 95901018.0 (22) Date of filing: 21.10.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 45/ 00( . ) A61P 35/ 00( . ) C07K 16/ 18( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 47( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1994/012058 (87) International publication number: WO 1996/012791 (02.05.1996 Gazette 1996/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: WEI, Ying-Fei Darnestown, MD 20878 (US) SUTTON, Granger, G., III Columbia, MD 21045 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)