HEPATITIS VIRUS B AND C VACCINES

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EP 0 789 563 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	17.11.2004 Bulletin 2004/47

(45)	Mention of the grant of the patent:
	16.06.2004 Bulletin 2004/25

(21)	Application number: 95938824.0

(22)	Date of filing: 05.10.1995

(51)	International Patent Classification (IPC)⁷: A61K 31/00, A61K 35/00, A61K 39/145, C12N 7/00, C12N 7/01, C07K 14/02, C07K 14/18, A61P 31/14

(86)	International application number:
	PCT/US1995/013552

(87)	International publication number:
	WO 1996/010997 (18.04.1996 Gazette 1996/17)

(54)	HEPATITIS VIRUS B AND C VACCINES IMPFSTOFFE GEGEN DEN HEPATITIS B UND C VIRUS VACCINS CONTRE LE VIRUS DE L'HEPATITE B ET C

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

05.10.1994 US 318248
06.06.1995 US 467859

(43)	Date of publication of application:
	20.08.1997 Bulletin 1997/34

(73)	Proprietors:
	APOLLON, INC. Malvern, PA 19355-1423 (US) The General Hospital Corporation doing business as The Massachusetts General Hospital Boston, MA 02114 (US)

(72)	Inventors:
	PACHUK, Catherine J. Lansdowne, PA 19050 (US) WANDS, Jack Waban, MA 02168 (US) WAKITA, Takaji Tokyo 175 (JP) ZURAWSKI, Vincent R., Jr. Westtown, PA 19393 (US) CONEY, Leslie R. Rosemont, PA 19010 (US) TOKUSHIGE, Katsutoshi Boston, MA 02114 (US)

(74)	Representative: Stebbing, Peter John Hunter
	Ablett & Stebbing, Caparo House, 101-103 Baker Street London W1M 1FD London W1M 1FD (GB)

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References cited: :

WO-A-93/15193
CA-A- 2 055 149
JP-A- 6 141 870

WO-A-93/15207
JP-A- 6 092 996

DATABASE WPI Section Ch, Week 9444 Derwent Publications Ltd., London, GB; Class B04, AN 94-354772 XP002072536 & JP 06 279 500 A (IMMUNO JAPAN KK)
MAJOR M E ET AL: "DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid" JOURNAL OF VIROLOGY., vol. 69, no. 9, September 1995, US, pages 5798-5805, XP002072535
JOURNAL OF VIROLOGY, Volume 67, Number 10, issued October 1993, YOSHIKAWA et al., "Chimeric Hepatitis B Virus Core Particles With Parts or Copies of the Hepatitis C Virus Core Protein", pages 6064-6070.
PROC. NATL. ACAD. SCI. U.S.A., Volume 83, issued December 1986, ITOH et al., "A Synthetic Peptide Vaccine Involving the Product of the Pre-S(2) Region of Hepatitis B Virus DNA: Protective Efficacy in Chimpanzees", pages 9174-9178.
PROC. NATL. ACAD. SCI. U.S.A., Volume 88, issued March 1991, HAN et al., "Characterization of the Terminal Regions of Hepatitis C Viral RNA: Identification of Conserved Sequences in the 5' Untranslated Region and Poly (A) Tails at the 3' End", pages 1711-1715.
FEBS, Volume 332, Number 1,2, issued October 1993, WELLS, "Improved Gene Transfer by Direct Plasmid Injection Associated With Regeneration in Mouse Skeletal Muscle", pages 179-182.
JOURNAL OF MEDICAL VIROLOGY, Volume 40, issued 1993, WANG et al., "Prevalence, Genotypes and an Isolate (HC-C2) of Hepatitis C Virus in Chinese Patients With Liver Disease", pages 254-260.
MICHEL M. ET AL: 'Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV-hepatitis B surface antigen particles' PNAS vol. 85, 1998, pages 7957 - 7961
DELPEYROUX F. ET AL: 'A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles' SCIENCE vol. 233, 1986, pages 472 - 475


	Remarks:
	The file contains technical information submitted after the application was filed and not included in this specification

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).