| (84) |
Designated Contracting States: |
|
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
| (30) |
Priority: |
02.11.1994 US 334029
07.06.1995 US 482401
|
| (43) |
Date of publication of application: |
|
20.08.1997 Bulletin 1997/34 |
| (60) |
Divisional application: |
|
08102871.4 / 1985703 |
| (73) |
Proprietors: |
|
- NPS PHARMACEUTICALS, INC.
Bedminster, NJ 07921 (US)
- THE RESEARCH FOUNDATION OF
STATE UNIVERSITY OF NEW YORK
Stony Brook, NY 11794-3366 (US)
|
|
| (72) |
Inventors: |
|
- MANDEL, Gail
Stony Brook, NY 11794 (US)
- HALEGOUA, Simon
Belle Terre, NY 11777 (US)
- BORDEN, Laurence A.
Hackensack, NJ 07601 (US)
|
| (74) |
Representative: Naylor, Kathryn May et al |
|
Mathys & Squire LLP
120 Holborn
London
EC1N 2SQ
London
EC1N 2SQ (GB) |
| (56) |
References cited: :
WO-A-90/09391
US-A- 5 380 836
|
US-A- 4 500 530
|
|
| |
|
|
- GAUTRON S. ET AL: "The glial voltage-gated sodium channel: Cell- and tissue-specific
mRNA expression" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES
OF AMERICA_(_PROC. NATL. ACAD. SCI. U. S. A._), 1992, 89/15 (7272-7276), XP002146639
United States
- OH Y. ET AL: "The beta1 subunit mRNA of the rat brain Nasup + channel is expressed
in glial cells" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES
OF AMERICA_(_PROC. NATL. ACAD. SCI. U. S. A._), 1994, 91/21 (9985-9989), XP002146640
United States
- OH Y. ET AL: "Rat brain Nasup + channel mRNAs in non-excitable Schwann cells" FEBS
LETTERS_(_FEBS LETT._), 1994, 350/2-3 (342-346), XP002146641 Netherlands
- BECKH S.: "Differential expression of sodium channel mRNAs in rat peripheral nervous
system and innervated tissues" FEBS LETTERS_(_FEBS LETT._), 1990, 262/2 (317-322),
XP002146642 Netherlands
- NODA M ET AL: "EXISTENCE OF DISTINCT SODIUM CHANNEL MESSENGER RNA IN RAT BRAIN" NATURE
(LONDON), vol. 320, no. 6058, 1986, pages 188-192, XP002146643 ISSN: 0028-0836
- MARTIN Y C ET AL: "MOLECULAR MODELING OF RECEPTOR-LIGAND INTERACTIONS" CLINICAL PHARMACOLOGY,
1989, pages 137-171, XP000939057 ISSN: 0892-001X
- DESJARLAIS R L ET AL: "USING SHAPE COMPLEMENTARITY AS AN INITIAL SCREEN IN DESIGNING
LIGANDS FOR A RECEPTOR BINDING SITE OF KNOWN THREE-DIMENSIONAL STRUCTURE" JOURNAL
OF MEDICINAL CHEMISTRY, vol. 31, no. 4, 1988, pages 722-729, XP000938991 ISSN: 0022-2623
- SINGH J ET AL: "A NOVEL METHOD FOR THE MODELLING OF PEPTIDE LIGANDS TO THEIR RECEPTORS"
PROTEIN ENGINEERING, vol. 4, no. 3, 1991, pages 251-262, XP000939012 ISSN: 0269-2139
- BELCHER SM ET AL: "Cloning of a sodium channel alpha subunit from rabbit Schwann cells."
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NOV
21 1995, 92 (24) P11034-8, XP002146644 UNITED STATES
- TOLEDO-ARAL JUAN J ET AL: "Identification of PN1, a predominant voltage-dependent
sodium channel expressed principally in peripheral neurons." PROCEEDINGS OF THE NATIONAL
ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 94, no. 4, 1997, pages 1527-1532, XP002146645
1997 ISSN: 0027-8424
- PROC. NATL. ACAD. SCI. U.S.A., Volume 89, issued September 1992, AHMED et al., "Primary
Structure, Chromosomal Localization and Functional Expression of a Voltage-Gated Sodium
Channel from Human Grain", pages 8220-8224.
- DNA AND CELL BIOLOGY, Volume 13, Number 1, issued 1994, SHENG et al., "Molecular Cloning
and Functional Analysis of the Promoter of Rat Skeletal Muscle Voltage-Sensitive Sodium
Channel Subtype 2 (rSkM2): Evidence for Muscle-Specific Nuclear Protein Binding to
the Core Promoter", pages 9-23.
- SCIENCE, Volume 269, issued 25 August 1995, MARSHALL, "Gene Therapy's Growing Pains",
pages 1050-1055.
- BIOPHYSICAL JOURNAL, Volume 66, issued January 1994, LIPKIND et al., "A Structural
Model of the Tetrodotoxin and Saxitoxin Binding Site of the Na+ Channel", pages 1-13.
- BIOCHEMISTRY, Volume 31, issued 1992, WAKAMATSU et al., "Structure-Activity Relationships
of u-Conotoxin GIIIA: Structure Determination of Active and Inactive Sodium Channel
Blocker Peptides by NMR and Simulated Annealing Conditions", pages 12577-12584.
- PROTEIN ENGINEERING, Volume 6, Number 1, issued 1993, SANSOM et al., "Influenza Virus
M2 Protein: A Molecular Modeling Study of the Ion Channel", pages 65-74.
- D'ARCANGELO G. ET AL: 'Neuronal growth factor regulation of two different sodium channel
types through distinct signal transduction pathway' THE JOURNAL OF CELL BIOLOGY vol.
122, no. 4, August 1993, UNITED STATES, pages 915 - 921
- CUMMINS T.R. ET AL: 'Slow closed-state inactivation: a novel mechanism underlying
ramp currents in cells expressing the hNE/PN1 sodium channel.' THE JOURNAL OF NEUROSCIENCE
vol. 18, no. 23, 01 December 1998, UNITED STATES, pages 9607 - 9619
- NASSAR MOHAMMED A. ET AL: 'Nociceptor-specific gene deletion reveals a major role
for Nav1.7 (PN1) in acute and inflammatory pain.' PROCEEDINGS OF THE NATIONAL ACADEMY
OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 101, no. 34, 24 August 2004, pages
12706 - 12711
|
|
