(19)

(11)

EP 0 789 695 A2

(12)

(43) Date of publication: 20.08.1997 Bulletin 1997/34 (21) Application number: 95940672.0 (22) Date of filing: 03.11.1995

(51) International Patent Classification (IPC):  A61K 31/ 38( . ) A61K 31/ 4436( . ) A61P 43/ 00( . ) C07D 409/ 12( . ) C07D 495/ 04( . ) A61K 31/ 427( . ) A61P 31/ 18( . ) C07D 337/ 04( . ) C07D 417/ 12( . ) C07D 495/ 12( . ) (86) International application number: PCT/US1995/014603 (87) International publication number: WO 1996/014314 (17.05.1996 Gazette 1996/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.11.1994 US 19940334471 06.06.1995 US 19950470864 07.06.1995 US 19950473876 02.11.1995 US 19950522042 (71) Applicant: GILEAD SCIENCES, INC. Foster City, CA 94404 (US)

(72) Inventors: BISCHOFBERGER, Norbert, W. San Carlos, CA 94070 (US) KIM, Choung, U. San Carlos, CA 94070 (US) KRAWCZYK, Steven, H. San Carlos, CA 94070 (US) MCGEE, Lawrence, R. Pacifica, CA 94044 (US) POSTICH, Michael J., Apartment 109 San Mateo, CA 94403 (US) YANG, Wenjin Foster City, CA 94404 (US) (74) Representative: Kinzebach, Werner, Dr., et al  Patent Attorneys, Reitstötter, Kinzebach & Partner, Sternwartstrasse 4 81679 München 81679 München (DE)