(19)
(11) EP 0 790 965 A1

(12)

(43) Date of publication:
27.08.1997 Bulletin 1997/35

(21) Application number: 95939047.0

(22) Date of filing: 06.11.1995
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
C07D 339/ 04( . )
C07B 59/ 00( . )
C07H 21/ 00( . )
(86) International application number:
PCT/US1995/014259
(87) International publication number:
WO 1996/014277 (17.05.1996 Gazette 1996/22)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 07.11.1994 US 19940335100
21.06.1995 US 19950493257
21.06.1995 US 19950493339

(71) Applicant: HYBRIDON, Inc.
Cambridge, MA 02139 (US)

(72) Inventors:
  • IYER, Radhakrishnan, P.
    Shrewsbury, MA 01545 (US)
  • AGRAWAL, Sudhir
    Shrewsbury, MA 01545 (US)
  • TAN, Weitian
    Framingham, MA 01701 (US)

(74) Representative: Vossius, Volker, Dr., et al 
Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5
81679 München
81679 München (DE)

   


(54) SYNTHESIS OF ?35 S-LABELED OLIGONUCLEOTIDES WITH 3H-1,2-BENZODITHIOL-3-1,1-DIOXIDE