(19)
(11) EP 0 791 058 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
17.02.2010 Bulletin 2010/07

(45) Mention of the grant of the patent:
30.12.2009 Bulletin 2009/53

(21) Application number: 95938418.1

(22) Date of filing: 06.11.1995
(51) International Patent Classification (IPC): 
C12N 15/11(2006.01)
C12N 15/66(2006.01)
 C12N 5/10(2006.01)
A01K 67/027(2006.01)
(86) International application number:
PCT/EP1995/004351
(87) International publication number:
WO 1996/014408 (17.05.1996 Gazette 1996/22)

(54)

USE OF A NUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEI

VERWENDUNG EINER NUKLEOTIDENSEQUENZ, DIE FUR ENZYM I-SCIE KODIERT

UTILISATIONS D'UNE SEQUENCE NUCLEOTIDIQUE CODANT L'ENZYME I-SCEI

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 07.11.1994 US 336241

(43) Date of publication of application:
27.08.1997 Bulletin 1997/35

(60) Divisional application:
09175319.4

(73) Proprietors:
  • INSTITUT PASTEUR
    75724 Paris Cedex 15 (FR)
  • UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    75252 Paris Cedex 05 (FR)

(72) Inventors:
  • CHOULIKA, André
    F-75015 Paris (FR)
  • PERRIN, Arnaud
    F-75014 Paris (FR)
  • DUJON, Bernard
    F-91190 Gif-sur-Yvette (FR)
  • NICOLAS, Jean-François
    F-78590 Noisy-le-Roi (FR)

(74) Representative: Desaix, Anne et al
Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber
75009 Paris
75009 Paris (FR)


(56) References cited: : 
US-A- 5 474 896
   
  • MOLECULAR AND CELLULAR BIOLOGY, vol. 14, no. 12, 1994, pages 8096--8106, XP002005200 P. ROUET ET AL.: "Introduction of double strand breaks into the genome of ouse cells by expression of a rare cutting endonuclease"
  • MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 4, 1995, pages 1868-1873, XP002005201 A. CHOULIKA ET AL.: "Induction of recombination in mammalian chromosomes by using the I-SceI system in S. cerevisiae"
  • NUCLEIC ACIDS RESEARCH, vol. 23, no. 24, 1995, pages 5012-5019, XP002005202 F. SMIH ET AL.: "Double strand breaks at the target locus stimulate gene targeting in embryonic stem cells"
  • COMPTES RENDUS DE L'ACADEMIE DES SCIENCES DE PARIS, vol. 317, 1994, pages 1013-1019, XP002005203 A. CHOULIKA ET AL.: "The yeast I-SceI meganuclease induces site-directed chromosomal recombination in mammalian cells"
  • NUCLEIC ACIDS RESEARCH, vol. 21, no. 22, 1993, pages 5034-5040, XP002005204 H. PUCHTA ET AL.: "Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site specific endonuclease"
  • PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 91, 1994, pages 6064-6068, XP002005205 P. ROUET ET AL.: "Expression of a site specific endonuclease stimulates homologous recombination in mammalian cells"
  • GENETICS, vol. 130, no. 3, 1992, pages 451-460, XP002005206 A. PLESSIS ET AL.: "Site specific recombination determined by I-Sce I, a mitochondrial group I intron encoded endonuclease expressed in the yeast nucleus"
   
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