ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE..................................................................*JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/00791058CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120100217W173deBibliographieenBibliographyfrBibliographieEP95938418.1199511061997040220020103enenen33624119941107US2010021720100719970827199735200912302009532009052520100217201007C12N 15/11 20060101AFI19960626BHEP C12N 5/10 20060101ALI19960626BHEP C12N 15/66 20060101ALI19960626BHEP A01K 67/027 20060101ALI19960626BHEP deVERWENDUNG EINER NUKLEOTIDENSEQUENZ, DIE FUR ENZYM I-SCIE KODIERTenUSE OF A NUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEIfrUTILISATIONS D'UNE SEQUENCE NUCLEOTIDIQUE CODANT L'ENZYME I-SCEIUS-A- 5 474 896MOLECULAR AND CELLULAR BIOLOGY, vol. 14, no. 12, 1994, pages 8096--8106, XP002005200 P. ROUET ET AL.: "Introduction of double strand breaks into the genome of ouse cells by expression of a rare cutting endonuclease"MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 4, 1995, pages 1868-1873, XP002005201 A. CHOULIKA ET AL.: "Induction of recombination in mammalian chromosomes by using the I-SceI system in S. cerevisiae"NUCLEIC ACIDS RESEARCH, vol. 23, no. 24, 1995, pages 5012-5019, XP002005202 F. SMIH ET AL.: "Double strand breaks at the target locus stimulate gene targeting in embryonic stem cells"COMPTES RENDUS DE L'ACADEMIE DES SCIENCES DE PARIS, vol. 317, 1994, pages 1013-1019, XP002005203 A. CHOULIKA ET AL.: "The yeast I-SceI meganuclease induces site-directed chromosomal recombination in mammalian cells"NUCLEIC ACIDS RESEARCH, vol. 21, no. 22, 1993, pages 5034-5040, XP002005204 H. PUCHTA ET AL.: "Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site specific endonuclease"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 91, 1994, pages 6064-6068, XP002005205 P. ROUET ET AL.: "Expression of a site specific endonuclease stimulates homologous recombination in mammalian cells"GENETICS, vol. 130, no. 3, 1992, pages 451-460, XP002005206 A. PLESSIS ET AL.: "Site specific recombination determined by I-Sce I, a mitochondrial group I intron encoded endonuclease expressed in the yeast nucleus"09175319.420091106CHOULIKA, André3, rue F.-MouthonF-75015 ParisFRPERRIN, Arnaud10, avenue P.-AppellF-75014 ParisFRDUJON, Bernard6, rue de la GruerieF-91190 Gif-sur-YvetteFRNICOLAS, Jean-François39, chemin de la SourceF-78590 Noisy-le-RoiFRINSTITUT PASTEUR00250790B3041A - AD25-28, rue du Docteur Roux75724 Paris Cedex 15FRUNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)10254550B3041A - AD4, place Jussieu75252 Paris Cedex 05FRDesaix, Anneet al00062911Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber75009 ParisFR010020020410ECELLECTIS S.A.0000794028 rue du Docteur Roux75724 Paris Cedex 15FRATBECHDEDKESFRGBGRIEITLILUMCNLPTSEATBECHDEDKESFRGBGRIEITLILUMCNLPTSEEP199500435119951106enWO19960144081996051719962219970827199735