CERTAIN 4-AMINOMETHYL-2-SUBSTITUTED IMIDAZOLE DERIVATIVES AND 2-AMINOMETHYL-4-SUBSTITUTED IMIDAZOLE DERIVATIVES; NEW CLASSES OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS - Patent 0793653

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(11)

EP 0 793 653 A1

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(43)	Date of publication:
	10.09.1997 Bulletin 1997/37

(21)	Application number: 95942473.0

(22)	Date of filing: 22.11.1995

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International Patent Classification (IPC):

C07D 233/ 64^{( . )}
A61K 31/ 415^{( . )}
A61K 31/ 4178^{( . )}
A61K 31/ 445^{( . )}
A61K 31/ 4523^{( . )}
A61K 31/ 506^{( . )}
A61P 25/ 16^{( . )}
A61P 25/ 24^{( . )}
A61P 43/ 00^{( . )}
C07D 401/ 06^{( . )}
C07D 401/ 14^{( . )}
C07D 487/ 08^{( . )}

A61K 31/ 00^{( . )}
A61K 31/ 4164^{( . )}
A61K 31/ 4427^{( . )}
A61K 31/ 4465^{( . )}
A61K 31/ 505^{( . )}
A61P 25/ 00^{( . )}
A61P 25/ 18^{( . )}
A61P 25/ 26^{( . )}
C07D 233/ 54^{( . )}
C07D 401/ 12^{( . )}
C07D 403/ 12^{( . )}

(86)	International application number:
	PCT/US1995/015262

(87)	International publication number:
	WO 1996/016040 (30.05.1996 Gazette 1996/25)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	LT LV SI

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Priority:

23.11.1994 US 19940344154
23.11.1994 US 19940344552
09.03.1995 US 19950401201

(71)	Applicant: NEUROGEN CORPORATION
	Branford, CT 06405 (US)

(72)	Inventors:
	THURKAUF, Andrew Danbury, CT 06811 (US) HORVATH, Raymond, F. North Branford, CT 06471 (US) YUAN, Jun Clinton, CT 06413 (US) PETERSON, John, M. New Haven, CT 06511 (US)

(74)	Representative: Eyles, Christopher Thomas
	W.P. THOMPSON & CO. Celcon House 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)

(54)	CERTAIN 4-AMINOMETHYL-2-SUBSTITUTED IMIDAZOLE DERIVATIVES AND 2-AMINOMETHYL-4-SUBSTITUTED IMIDAZOLE DERIVATIVES; NEW CLASSES OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS