(19)

(11)

EP 0 793 677 A1

(12)

(43) Date of publication: 10.09.1997 Bulletin 1997/37 (21) Application number: 95944577.0 (22) Date of filing: 28.12.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 29/ 00( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) C07K 14/ 705( . ) (86) International application number: PCT/US1995/017095 (87) International publication number: WO 1996/020957 (11.07.1996 Gazette 1996/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 30.12.1994 US 19940366953 07.06.1995 US 19950484397 (71) Applicants: AMGEN INC. Thousand Oaks, CA 91320-1789 (US) THE ROCKEFELLER UNIVERSITY New York New York 10021-6399 (US)	(72) Inventors: JUAN, Shao Chieh Moorpark, CA 93021 (US) LICHENSTEIN, Henri S. Ventura, CA 73004 (US) WRIGHT, Samuel D. Larchmont, NY 10538 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)