(19)

(11)

EP 0 794 773 A1

(12)

(43) Date of publication: 17.09.1997 Bulletin 1997/38 (21) Application number: 95943943.0 (22) Date of filing: 21.12.1995

(51) International Patent Classification (IPC):  C07D 213/ 28( . ) C07D 213/ 30( . ) A61K 31/ 44( . ) C07D 213/ 38( . ) (86) International application number: PCT/US1995/016712 (87) International publication number: WO 1996/019986 (04.07.1996 Gazette 1996/30)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 23.12.1994 US 19940363668 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: CHRISTENSEN, Siegfried B., IV Philadelphia, PA 19103 (US) KARPINSKI, Joseph M. Pottstown, PA 19464 (US) RYAN, M.Dominic Pottstown, PA 19464 (US) BENDER, Paul E. Cherry Hill, NJ 08003 (US) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)