(19)

(11)

EP 0 796 252 A1

(12)

(43) Date of publication: 24.09.1997 Bulletin 1997/39 (21) Application number: 95942590.0 (22) Date of filing: 07.12.1995

(51) International Patent Classification (IPC):  A61K 31/ 55( . ) A61P 7/ 02( . ) C07D 243/ 14( . ) C07D 243/ 24( . ) A61K 31/ 551( . ) C07D 223/ 16( . ) C07D 243/ 16( . ) (86) International application number: PCT/US1995/015932 (87) International publication number: WO 1996/017833 (13.06.1996 Gazette 1996/27)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 09.12.1994 US 19940353045 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: CALLAHAN, James, Francis Philadelphia, PA 19111 (US) SAMANEN, James, Martin Phoenixville, PA 19460 (US) (74) Representative: Valentine, Jill Barbara  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)