(19)

(11)

EP 0 796 331 A2

(12)

(43) Date of publication: 24.09.1997 Bulletin 1997/39 (21) Application number: 95944227.0 (22) Date of filing: 22.12.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 00( . ) A61P 31/ 12( . ) C07K 14/ 075( . ) C07K 14/ 755( . ) C12N 9/ 12( . ) C12N 15/ 19( . ) C12P 21/ 02( . ) C12R 1/ 92( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C07K 14/ 61( . ) C12N 7/ 00( . ) C12N 15/ 00( . ) C12N 15/ 867( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1995/016852 (87) International publication number: WO 1996/021014 (11.07.1996 Gazette 1996/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.12.1994 US 19940367071 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)

(72) Inventors: JOLLY, Douglas J. Leucadia, CA 92024 (US) BARBER, Jack R. San Diego, CA 92129 (US) CHANG, Stephen M.W. Poway, CA 92064 (US) CHANG, Stephen M.W. Poway, CA 92064 (US) ALLEN, John R. Vista Ridge, CA 92083 (US) BODNER, Mordechai San Diego, CA 92104 (US) CHONG, Kimberly San Diego, CA 92128 (US) DE LA VEGA, Dan, Jr. San Diego, CA 92104 (US) DePOLO, Nicholas J. Solana Beach, CA 92605 (US) HSU, David Chi-Tang San Diego, CA 92122 (US) IBANEZ, Carlos E. San Diego, CA 92129 (US) MITTELSTAEDT, Denice M. San Diego, CA 92129 (US) PRUSSAK, Charles E. San Diego, CA 92124 (US) (74) Representative: Irvine, Jonquil Claire, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)