(19)

(11)

EP 0 796 334 A1

(12)

(43) Date of publication: 24.09.1997 Bulletin 1997/39 (21) Application number: 95939599.0 (22) Date of filing: 26.10.1995

(51) International Patent Classification (IPC):  C07K 16/ 18( . ) C07K 16/ 34( . ) A61K 38/ 00( . ) C07K 16/ 30( . ) C07K 19/ 00( . ) (86) International application number: PCT/US1995/013811 (87) International publication number: WO 1996/013594 (09.05.1996 Gazette 1996/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.10.1994 US 19940331396 28.10.1994 US 19940331397 28.10.1994 US 19940331398 (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Bethesda, MD 20892-9902 (US)

(72) Inventors: PASTAN, Ira Potomac, MD 20854 (US) BENHAR, Itai Rockville, MD 20852 (US) PADLAN, Eduardo, A. Kensington, MD 20895 (US) JUNG, Sun-Hee Rockville, MD 20852 (US) LEE, Byungkook Potomac, MD 20854 (US) WILLINGHAM, Mark Summerville, SC 29483 (US) FITZGERALD, David Rockville, MD 20850 (US) BRINKMANN, Ulrich Kensington, MD 20895 (US) PAI, Lee Silver Spring, MD 20906 (US) (74) Representative: Hotz, Klaus, Dipl.-El.-Ing./ETH Patentanwalt  c/o OK pat AG Hinterbergstrasse 36 Postfach 5254 6330 Cham 6330 Cham (CH)