(19)

(11)

EP 0 796 342 A2

(12)

(43) Date of publication: 24.09.1997 Bulletin 1997/39 (21) Application number: 95938560.0 (22) Date of filing: 07.12.1995

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) A61K 38/ 45( . ) A61P 7/ 04( . ) A61P 15/ 00( . ) C12Q 1/ 68( . ) A61K 38/ 43( . ) A61K 45/ 00( . ) A61P 13/ 02( . ) C12N 15/ 09( . ) (86) International application number: PCT/GB1995/002857 (87) International publication number: WO 1996/017953 (13.06.1996 Gazette 1996/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.12.1994 GB 19940024823 (71) Applicant: THE UNIVERSITY OF LEEDS Leeds, LS2 9JT (GB)	(72) Inventors: MARKHAM, Alexander, Fred Cheshire CW4 8NA (GB) Anwar, Rashida Roundhay, Leeds LS8 2BX (GB) Miloszewski, Krzystof Jozef Antoni Leeds LS8 2BS, West Yorkshire (GB) (74) Representative: Fyles, Julie Marie, et al  William Jones, The Crescent, 54 Blossom Street York YO2 2AP York YO2 2AP (GB)