(19)

(11)

EP 0 797 583 A1

(12)

(43) Date of publication: 01.10.1997 Bulletin 1997/40 (21) Application number: 95942131.0 (22) Date of filing: 12.12.1995

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 29/ 00( . ) C07D 403/ 12( . ) C07K 1/ 113( . ) A61P 25/ 04( . ) C07D 401/ 14( . ) C07D 411/ 12( . ) C07K 5/ 078( . ) (86) International application number: PCT/EP1995/004910 (87) International publication number: WO 1996/018643 (20.06.1996 Gazette 1996/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE Designated Extension States: SI (30) Priority: 13.12.1994 GB 19940025085 22.12.1994 GB 19940026016 (71) Applicants: Novartis AG 4058 Basel (CH) SANDOZ-PATENT-GMBH 79539 Lörrach (DE) SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. 1230 Wien (AT) SANDOZ PHARMACEUTICALS (UK) LTD. Horsforth Leeds LS18 4RP (GB)	(72) Inventors: KO, Soo, Young London NW3 4LY (GB) WALPOLE, Christopher Hackney London E8 1PA (GB) (74) Representative: Grange, Gordon, et al  c/o Novartis AG, Patents- & Trademarks Division, Lichtstrasse 35 4002 Basel 4002 Basel (CH)