(19)

(11)

EP 0 797 659 A1

(12)

(43) Date of publication: 01.10.1997 Bulletin 1997/40 (21) Application number: 96941335.0 (22) Date of filing: 06.11.1996

(51) International Patent Classification (IPC):  A01H 5/ 00( . ) A01N 63/ 02( . ) C07K 14/ 24( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) A01N 63/ 00( . ) C07K 14/ 195( . ) C12N 1/ 20( . ) C12N 9/ 52( . ) C12N 15/ 82( . ) (86) International application number: PCT/US1996/018003 (87) International publication number: WO 1997/017432 (15.05.1997 Gazette 1997/21)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.11.1995 US 19950007255P 28.02.1996 US 19960608423 28.08.1996 US 19960705484 (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, Wisconsin 53707-7365 (US)

(72) Inventors: ENSIGN, Jerald C. Madison, WI 53705 (US) BOWEN, David J. Oregon, WI 53575 (US) PETELL, James Zionsville, IN 46077 (US) FATIG, Raymond Zionsville, IN 46077 (US) SCHOONOVER, Sue Brownsburg, IN 46112 (US) FFRENCH-CONSTANT, Richard H. Madison, WI 53705 (US) ROCHELEAU, Thomas A. Madison, WI 53704 (US) BLACKBURN, Michael B. Madison, WI 53713 (US) HEY, Timothy D. Zionsville, IN 46077 (US) MERLO, Donald J. Carmel, IN 46032 (US) ORR, Gregory L. Indianapolis, IN 46280 (US) ROBERTS, Jean L. Arcadia, IN 46030 (US) STRICKLAND, James A. Lebanon, IN 46052 (US) GUO, Lining Brownsburg, IN 46112 (US) CICHE, Todd A. Madison, WI 53705 (US) (74) Representative: Raynor, John, et al  W.H. Beck, Greener & Co 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)