(19)
(11) EP 0 799 240 A1

(12)

(43) Date of publication:
08.10.1997 Bulletin 1997/41

(21) Application number: 95940926.0

(22) Date of filing: 21.12.1995
(51) International Patent Classification (IPC): 
C07D 417/ 12( . )
A61P 7/ 02( . )
C07K 5/ 087( . )
 A61K 31/ 425( . )
C07K 5/ 065( . )
A61K 38/ 00( . )
(86) International application number:
PCT/CA1995/000711
(87) International publication number:
WO 1996/019491 (27.06.1996 Gazette 1996/29)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
LT LV SI

(30) Priority: 22.12.1994 GB 19940026038
17.02.1995 GB 19950003136
06.03.1995 GB 19950004404
06.03.1995 GB 19950004403

(71) Applicant: BIOCHEM PHARMA INC.
Laval, Quebec H7V 4A7 (CA)

(72) Inventors:
  • GILLARD, John
    Baie D'Urfé, Quebec H9X 2S1 (CA)
  • DIMAIO, John
    Montreal, Quebec H1E 4L9 (CA)
  • SIDDIQUI, M., Arshad
    St-Laurent, Quebec H4R 2C4 (CA)
  • PREVILLE, Patrice
    St-Charles Borromée, Quebec J6E 7H9 (CA)
  • LAFLEUR, Dominique
    Ste-Dorothée, Quebec H7W 3S6 (CA)
  • EDMUNDS, John
    Ypsilanti, MI 48197 (US)
  • DOHERTY, Annette, Marian
    Ann Arbor, MI 48103 (US)

(74) Representative: Jones, Helen Marjorie Meredith, et al 
Gill Jennings & Every, Broadgate House, 7 Eldon Street
London EC2M 7LH
London EC2M 7LH (GB)

   


(54) HETEROCYCLIC KETO ARGININE PEPTIDES AS THROMBIN INHIBITORS