(19)
(11) EP 0 799 314 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.10.2003 Bulletin 2003/40

(45) Mention of the grant of the patent:
14.05.2003 Bulletin 2003/20

(21) Application number: 95943378.0

(22) Date of filing: 06.12.1995
(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/12, C12Q 1/68, C07K 16/40, C12N 5/12, G01N 33/68, C12Q 1/48, C07D 241/40, C07C 255/34, C07D 215/00, C07D 239/72
(86) International application number:
PCT/US9515/846
(87) International publication number:
WO 9601/8738 (20.06.1996 Gazette 1996/28)

(54)

PROTEIN TYROSINE KINASES (PYK2) ITS cDNA CLONING AND ITS USES

PROTEIN TYROSINE KINASE (PYK2), IHRE CDNA KLONIERUNG UND IHRE VERWENDUNGEN

PROTEINE TYROSINE KINASES (PYK2), SON CLONAGE PAR ADNc ET SON UTILISATION

(84) Designated Contracting States:
CH DE FR GB IT LI

(30) Priority: 15.12.1994 US 357642
02.06.1995 US 460626

(43) Date of publication of application:
08.10.1997 Bulletin 1997/41

(60) Divisional application:
03007031.2

(73) Proprietors:
  • Sugen, Inc.
    South San Francisco, CA 94080 (US)
  • NEW YORK UNIVERSITY
    New York, NY 10012 (US)

(72) Inventors:
  • LEV, Sima
    San Francisco, CA 94122 (US)
  • SCHLESSINGER, Joseph
    New York, NY 10011 (US)

(74) Representative: Viering, Jentschura & Partner 
Postfach 22 14 43
80504 München
80504 München (DE)


(56) References cited: : 
   
  • PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, June 1992, WASHINGTON US, pages 5192-5196, XP002003601 M.D. SCHALLER ET AL: "pp125FAK , a structurally distinctive protein-tyrosine kinase associated with focal adhesions"
  • DNA CELL BIOLOGY, vol. 12, no. 9, 1993, pages 823-830, XP000570430 G. S. WHITNEY ET AL: "Human T and B lymphocytes express a structurally conserved Focal Adhesion Kinase, pp125FAK"
  • THE JOURNAL OF CELL BIOLOGY, vol. 123, no. 4, November 1993, pages 993-1005, XP000569388 J. D. HILDEBRAND ET AL: "Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions" cited in the application
  • NATURE, vol. 376, 31 August 1995, LONDON GB, pages 737-745, XP002003602 S. LEV ET AL: "Protein tyrosine kinase PYK involved in Ca2+-induced regulation of ion channel and MAP kinase functions"
  • JOURNAL OF IMMUNOLOGY, vol. 151, no. 5, 1 September 1993, BALTIMORE US, pages 2717-2724, XP002003603 Z. DONG ET AL: "Protein Tyrosine Kinase inhibitors decrease induction of nitrite oxide synthase activity in lipopolysaccharide-responsive and lipopolysacharide-nonresponsive murine macrophages" cited in the application
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).