(19)

(11)

EP 0 799 315 A2

(12)

(43) Date of publication: 08.10.1997 Bulletin 1997/41 (21) Application number: 95943470.0 (22) Date of filing: 18.12.1995

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61K 35/ 76( . ) A61K 39/ 395( . ) A61K 48/ 00( . ) A61P 31/ 12( . ) A61P 43/ 00( . ) C12N 1/ 21( . ) C12N 9/ 12( . ) C12N 15/ 54( . ) G01N 33/ 573( . ) C12R 1/ 19( . ) A61K 31/ 70( . ) A61K 38/ 55( . ) A61K 45/ 00( . ) A61P 31/ 00( . ) A61P 35/ 00( . ) C07K 16/ 40( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1995/016531 (87) International publication number: WO 1996/019580 (27.06.1996 Gazette 1996/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.12.1994 US 19940359125 (71) Applicant: COLD SPRING HARBOR LABORATORY Cold Spring Harbor, NY 11724 (US)

(72) Inventors: GREIDER, Carol Huntington, NY 11743 (US) COLLINS, Kathleen Huntington, NY 11743 (US) KOBAYASHI, Ryuji Syosset, NY 11791 (US) YANG, Xiaohong, Helena Greenlawn, NY 11740 (US) HEMISH, Jill, M. Huntington Station, NY 11746 (US) AUTEXIER, Chantal East Northport, NY 11731 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co. 3 Gray's Inn Square London WC1R 5AH London WC1R 5AH (GB)