(19)

(11)

EP 0 800 393 A1

(12)

(43) Date of publication: 15.10.1997 Bulletin 1997/42 (21) Application number: 95944527.0 (22) Date of filing: 21.12.1995

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) C07C 45/ 68( . ) C07C 59/ 90( . ) C07C 69/ 14( . ) C07C 233/ 33( . ) C07D 213/ 50( . ) C07D 239/ 26( . ) C07D 239/ 42( . ) C07D 271/ 10( . ) C07D 295/ 185( . ) C07D 333/ 38( . ) C07D 405/ 10( . ) C07C 45/ 59( . ) C07C 49/ 753( . ) C07C 65/ 40( . ) C07C 225/ 22( . ) C07C 255/ 56( . ) C07D 233/ 54( . ) C07D 239/ 38( . ) C07D 271/ 06( . ) C07D 285/ 12( . ) C07D 317/ 72( . ) C07D 405/ 08( . ) C07D 413/ 04( . ) (86) International application number: PCT/US1995/016858 (87) International publication number: WO 1996/019995 (04.07.1996 Gazette 1996/30)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 23.12.1994 US 19940363130 31.05.1995 US 19950456234 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: CHRISTENSEN, Siegfried B., IV Philadelphia, PA 19103 (US) KARPINSKI, Joseph M. Pottstown, PA 19464 (US) RYAN, M.Dominic Pottstown, PA 19464 (US) BENDER, Paul E. Cherry Hill, NJ 08003 (US) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)