(19)

(11)

EP 0 800 402 A1

(12)

(43) Date of publication: 15.10.1997 Bulletin 1997/42 (21) Application number: 95940384.0 (22) Date of filing: 15.12.1995

(51) International Patent Classification (IPC):  A61K 38/ 19( . ) A61K 38/ 20( . ) (86) International application number: PCT/GB1995/002929 (87) International publication number: WO 1996/019234 (27.06.1996 Gazette 1996/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 22.12.1994 GB 19940026012 (71) Applicant: BRITISH BIOTECH PHARMACEUTICALS LIMITED Cowley Oxford, OX4 5LY (GB)

(72) Inventors: McCOURT, Matthew, John Watlington Road Cowley Oxford OX4 5LY (GB) WOOD, Lars, Michael Watlington Road Cowley Oxford OX4 5LY (GB) HUNTER, Michael, George Watlington Road Cowley Oxford OX4 5LY (GB) CZAPLEWSKI, Lloyd, George Watlington Road Cowley Oxford OX4 5LY (GB) (74) Representative: Walls, Alan James  British Biotech Pharmaceuticals Ltd., Watlington Road Oxford OX4 5LY Oxford OX4 5LY (GB)