ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY

(19)

(11)

EP 0 800 517 A1

(12)

(43)	Date of publication:
	15.10.1997 Bulletin 1997/42

(21)	Application number: 95943828.0

(22)	Date of filing: 14.12.1995

(51)

International Patent Classification (IPC):

A61K 31/ 192^{( . )}
A61K 31/ 341^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 426^{( . )}
A61K 31/ 4433^{( . )}
A61P 3/ 06^{( . )}
A61P 11/ 00^{( . )}
A61P 11/ 10^{( . )}
A61P 29/ 00^{( . )}
C07C 17/ 10^{( . )}
C07C 17/ 35^{( . )}
C07C 45/ 67^{( . )}
C07C 49/ 697^{( . )}
C07C 65/ 19^{( . )}
C07C 65/ 38^{( . )}
C07C 69/ 76^{( . )}
C07C 229/ 50^{( . )}
C07C 233/ 58^{( . )}
C07C 251/ 48^{( . )}
C07C 255/ 47^{( . )}
C07C 317/ 44^{( . )}
C07C 327/ 32^{( . )}
C07D 213/ 80^{( . )}
C07D 277/ 24^{( . )}
C07D 277/ 30^{( . )}
C07D 309/ 06^{( . )}
C07D 309/ 12^{( . )}
C07D 339/ 08^{( . )}
C07F 7/ 08^{( . )}

A61K 31/ 235^{( . )}
A61K 31/ 351^{( . )}
A61K 31/ 385^{( . )}
A61K 31/ 4402^{( . )}
A61P 3/ 02^{( . )}
A61P 9/ 00^{( . )}
A61P 11/ 06^{( . )}
A61P 27/ 02^{( . )}
A61P 35/ 00^{( . )}
C07C 17/ 26^{( . )}
C07C 45/ 28^{( . )}
C07C 45/ 68^{( . )}
C07C 63/ 66^{( . )}
C07C 65/ 28^{( . )}
C07C 69/ 732^{( . )}
C07C 229/ 46^{( . )}
C07C 233/ 55^{( . )}
C07C 251/ 44^{( . )}
C07C 255/ 41^{( . )}
C07C 309/ 65^{( . )}
C07C 323/ 61^{( . )}
C07D 213/ 55^{( . )}
C07D 277/ 20^{( . )}
C07D 277/ 26^{( . )}
C07D 307/ 54^{( . )}
C07D 309/ 08^{( . )}
C07D 333/ 24^{( . )}
C07D 405/ 10^{( . )}
C07F 7/ 18^{( . )}

(86)	International application number:
	PCT/US1995/016367

(87)	International publication number:
	WO 1996/020930 (11.07.1996 Gazette 1996/31)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30)

Priority:

29.12.1994 US 19940366172
29.12.1994 US 19940366167
29.12.1994 US 19940366168
29.12.1994 US 19940366169
29.12.1994 US 19940366182
29.12.1994 US 19940366183
29.12.1994 US 19940366193

(71)	Applicant: Allergan
	Waco, TX 76712 (US)

(72)

Inventors:

VULIGONDA, Vidyasagar
Irvine, CA 92714 (US)
TENG, Min
Aliso Viejo, CA 92656 (US)
BEARD, Richard, L.
Newport Beach, CA 92660 (US)
JOHNSON, Alan, T.
Rancho Santa Margarita, CA 92688 (US)
LIN, Yuan
Walnut, CA 91789 (US)
CHANDRARATNA, Roshantha, A.
Mission Viejo, CA 92691 (US)
SONG, Tae, K.
Long Beach, CA 90807 (US)
WONG, Harold, N.
Rancho Santa Margarita, CA 92688 (US)
DUONG, Tien, T.
Irvine, CA 92714 (US)
GILLETT, Samuel, J.
Albany, CA 94706 (US)

(74)	Representative: Hutchins, Michael Richard, et al
	FRY HEATH & SPENCE The Old College 53 High Street Horley Surrey RH6 7BN Horley Surrey RH6 7BN (GB)

(54)	ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY