(19)

(11)

EP 0 801 526 A1

(12)

(43) Date of publication: 22.10.1997 Bulletin 1997/43 (21) Application number: 95944444.0 (22) Date of filing: 29.12.1995

(51) International Patent Classification (IPC):  C12N 15/ 86( . ) (86) International application number: PCT/US1995/017065 (87) International publication number: WO 1996/020598 (11.07.1996 Gazette 1996/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.12.1994 US 19940367002 (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia Pennsylvania 19107 (US)	(72) Inventor: STRAYER, David, S. Newtown Square, PA 19073 (US) (74) Representative: Stebbing, Peter John Hunter, et al  Ablett & Stebbing 45 Lancaster Mews Lancaster Gate London W2 3QQ London W2 3QQ (GB)