(19)

(11)

EP 0 802 921 A1

(12)

(43) Date of publication: 29.10.1997 Bulletin 1997/44 (21) Application number: 96903482.0 (22) Date of filing: 05.01.1996

(51) International Patent Classification (IPC):  G01N 33/ 566( . ) A61K 38/ 55( . ) A61P 29/ 00( . ) A61P 37/ 00( . ) C12N 9/ 12( . ) C12P 21/ 04( . ) A61K 31/ 70( . ) A61P 25/ 00( . ) A61P 35/ 02( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) G01N 33/ 15( . ) (86) International application number: PCT/US1996/000487 (87) International publication number: WO 1996/020948 (11.07.1996 Gazette 1996/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.01.1995 US 19950369780 (71) Applicant: ONYX PHARMACEUTICALS, INC. Richmond, CA 94806 (US)	(72) Inventors: ABO, Arie San Francisco, CA 94123 (US) MARTIN, George, A. Berkeley, CA 94702 (US) (74) Representative: Armitage, Ian Michael, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)