(19)

(11)

EP 0 802 973 A1

(12)

(43) Date of publication: 29.10.1997 Bulletin 1997/44 (21) Application number: 94927325.0 (22) Date of filing: 30.08.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 9/ 52( . ) C12Q 1/ 37( . ) C12R 1/ 46( . ) C12N 1/ 21( . ) C12N 15/ 57( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1994/009926 (87) International publication number: WO 1995/006721 (09.03.1995 Gazette 1995/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.09.1993 US 19930115227 22.08.1994 US 19940294189 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventors: FISCHETTI, Vincent A. West Hempstead, NY 11552 (US) RAKONJAC, Jasna New York, NY 10021 (US) ROBBINS, John New York, NY 10021 (US) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)