(19)

(11)

EP 0 804 157 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95912746.0 (22) Date of filing: 02.03.1995

(51) International Patent Classification (IPC):  A61K 9/ 12( . ) A61K 9/ 72( . ) A61K 47/ 22( . ) A61K 9/ 00( . ) A61K 31/ 355( . ) (86) International application number: PCT/US1995/002764 (87) International publication number: WO 1995/024892 (21.09.1995 Gazette 1995/40)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 14.03.1994 US 19940212472 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: FU LU, Mou-Ying Lake Bluff, IL 60044 (US) GUPTA, Pramod K. Gurnee, IL 60031 (US) ADJEI, Akwete L. Wadsworth, IL 60083 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)